Substances, mixtures, and exposure circumstances in this list have been classified as Group 1 by the International Agency for Research on Cancer (IARC): The agent (mixture) is carcinogenic to humans. Benzene is shipped by rail tank cars, trucks, barges, and tankers. benzene is carcinogenic to humans. Because of the flammability, toxicity, and volatility of benzene, transfers from one vessel to another are conducted in closed systems. benzene leads to aplastic anemia, and may lead to leukemia after 6 months to 6 years of chronic exposure. 1. The main way people are exposed is by breathing in air containing benzene. Information on Registered Substances comes from registration dossiers which have been assigned a registration number. Benzene (C6H6) is a highly flammable, colorless liquid that evaporates quickly into the air. Benzene exposure can cause chromosomal aberrations in animals and humans. Benzene is classified as a human carcinogen … Benzene is classified as a carcinogen, which increases the risk of cancer and other illnesses, and is also a notorious cause of bone marrow failure. Benzene evaporates into the air very quickly. Because of the distinctive smell of benzene (and related compounds), the benzene family is classified as “aromatic”; thus, the name, aromatic hydrocarbon. Benzene is a colourless liquid with a gasoline-like odour. It is now considered aromatic because it obeys Hückel's rule: 4n + 2 = number of π electrons in the hydrocarbon, where n must be an integer. Aromatic compounds are compounds that resemble benzene in chemical behavior thus they tend to react by substitution rather than by addition and fulfill the aromaticity requirements. The assignment of a registration number does however not guarantee that the … DOT ID & Guide. The exposure circumstance entails exposures that are carcinogenic to humans. To be classified as aromatic, a compound must have : Cyclic structure. A number of studies and reviews have linked Benzene exposure to certain forms of leukemia. Chronic benzene exposure has also been associated with lung cancer in epidemiological studies. If there are other groups present on the benzene ring the compound is said to be a substituted benzene. Appropriate personal protective equipment practices and labeling, storage, and transportation procedures must be followed. Benzene. Compounds containing benzene rings (see above) are aromatic compounds. Significantly increased risks of leukemia, chiefly acute myelogenous leukemia, have been reported in benzene-exposed workers in the chemical industry, shoemaking, … The benzene molecular structure is made of six carbon atoms arranged in a ring with one atom of hydrogen attached to each carbon atom. Benzene is classified as a known human carcinogen by various regulatory agencies worldwide. The chemical properties of substituted benzenes are determined both by the aromatic groups and by the properties of the group … Benzene is an aromatic hydrocarbon because it obeys Hückel's rule. As mentioned previously, the phenyl group (Ph-R, C 6 H 5-R) can be formed by removing a hydrogen from benzene and attaching a substituent to where the hydrogen was removed.To this phenomenon, we can name compounds formed this way by applying this rule: (phenyl + substituent).For example, a … Uses. CY1400000. Benzene is classified as a “known” human carcinogen (Category A) under the EPA Risk Assessment Guidelines of 1986. THE FACTS BENZENE Benzene is classified as Group 1 carcinogen by the IARC, meaning it is seen as a definite cause of cancer in humans. Its vapor is heavier than air and may sink into low-lying areas. The level of exposure depends upon the dose, duration, and work being … Safety Data Sheet – Benzene Revision Nr: 3 Issue date: 15/12/2014 Supersedes: 12/08/2011 Full text of H-phrases: see section 16 2.1.2. Planar structure. Benzene can cause blood cancers like leukemia. Other articles where Benzene ring is discussed: hydrocarbon: Aromatic hydrocarbons: …All compounds that contain a benzene ring possess special stability and are classified as benzenoid aromatic compounds. a. Benzene is a chemical that is a colorless or light yellow liquid at room temperature. It is highly toxic and is a known carcinogen; exposure to it may cause leukemia. Benzene is classified as “Carcinogenic to Humans” by the World Health Organization. c. It contains at least one C=C bond. The Phenyl Group. Benzene is classified as a flammable liquid and should be stored away from any potential source of ignition. Benzene is also classified as a known human carcinogen (category A) by the EPA and American Conference of Governmental Industrial Hygienists (ACGIH). It is classified as a hydrocarbon as it has only carbon and hydrogen atoms. Because benzene is a Category 1 carcinogen (i.e., a known or presumed human carcinogen), a mixture containing benzene at a concentration greater than or equal to 0.1% would be classified as a Category 1 carcinogen and require appropriate hazard information on the product’s label and SDS. Further, the relevant product Material Benzene evaporates quickly when exposed to the air and has a sweet smell. Leukemia is a malignant disease that affects the blood and bone marrow. Benzene and its metabolites may cause leukemia via genotoxic effects on the pluripotent hematopoietic stem cells, resulting in chromosomal changes . Substantial quantities of epidemiologic, clinical, and laboratory data link benzene to aplastic anemia, acute leukemia, bone marrow abnormalities and cardiovascular disease. Benzene is the simplest aromatic hydrocarbon and belongs to the group volatile organic compounds (VOC). - Benzene is a liquid at room temperature It is fragrant. It is cyclic. b. In the United States, the Environmental Protection Agency (EPA), Centers for Disease Control and Prevention (CDC), Food and Drug Administration (FDA), and National Institutes of Health (NIH) all classify benzene as either … Benzene dissolves only slightly in water and will float on top of water. This classification is reflected in these recommendations for respiratory protection, which specify that only the most reliable and protective respirators be worn at any detectable concentration. In modern usage, we use the term organic to describe a type of farming was intended to be healthier for humans. Benzene. Under the proposed revised Carcinogen Risk Assessment Guidelines (U.S. EPA, 1996), benzene is characterized as a known human carcinogen for all routes of exposure based upon convincing … Synonyms & Trade Names Benzol, Phenyl hydride CAS No. Certain other compounds lack a benzene ring yet satisfy the criterion of special stability and are classified as … In the case of benzene… Chemicals that are composed of only hydrogen and carbon are called hydrocarbons. It is highly flammable and has low water solubility. NOTE: NIOSH has classified this substance as a potential occupational carcinogen, according to specific NIOSH criteria. It is classified by the International Agency for Research on Cancer as a Group 1 human carcinogen. Benzene is an organic chemical with the chemical formula C 6 H 6 and CAS number 71-43-2. benzene is an unsaturated hydrocarbon. Benzene is a well-known environmental contaminant that was classified as a human carcinogen (IARC Group 1) in 1974 , which was recently reconfirmed . Occupational exposure to benzene is linked to leukemia. Basis: Benzene is classified as a "known" human carcinogen (Category A) under the Risk Assessment Guidelines of 1986. Consequently, benzene is classified as T, Cat 1 (H372) according to Regulation (EC) No 1272/2008 of the European Parliament. An organic compound is classified as aromatic if it fits which of the following criteria? Under the proposed revised Carcinogen Risk Assessment Guidelines (U.S. EPA, 1996), benzene is characterized as a known human carcinogen for all routes of exposure based upon convincing … Benzene derived products are well known to be pleasantly fragrant.For this reason, organic compounds containing benzene rings were classified as being "aromatic" (sweet smelling) amongst scientists in the early 19th century when a relation was established between benzene derived compounds and sweet/spicy … Long-term exposure to benzene may increase the incidence of a specific type of leukemia (acute myelogenous leukemia) and may be associated with other forms of leukemia and lymphomas (cancers that develop from cells in the lymphatic system). Benzene is known to cause acute myeloid leukaemia/acute non-lymphocytic leukaemia and potentially other cancers in humans. for Research on Cancer has classified benzene as : carcinogenic to humans (Group 1). Basis: Benzene is classified as a "known" human carcinogen (Category A) under the Risk Assessment Guidelines of 1986. It has a sweet odor and is highly flammable. Workers may be harmed from exposure to benzene. Benzene is considered to be unsaturated because it has double carbon-carbon covalent bonds. Individuals EWG’s Skin Deep rates thousands of personal care product ingredients, culled from ingredient labels on products, based on hazard information pulled from the scientific literature and industry, academic and regulatory databases. The link between benzene and cancer has largely focused on leukemia and other cancers of blood cells. Originally, benzene was considered aromatic because of its smell: it has an "aromatic" odor. which of the following is NOT a property of benzene? Formula. Benzene is a component of man-made fragrances that are added cosmetics. Alternating Л and δ bonds - Benzene undergoes the same reactions that other unsaturated hydrocarbons do. The ICH has classified benzene as a Class 1 solvent with a limit of NMT 2 ppm [2], and people in pharma and pharma-related industries are very concerned about controlling and minimizing the levels of benzene … This a different use of the word. - Benzene has a ring of carbon atoms in its structure. Benzene is classified as a Group 1 carcinogen. Benzene is known as an “aromatic hydrocarbon”. Related Pages. Benzene is a colourless liquid with a characteristic odour and is primarily used in the production of polystyrene. - Benzene contains only carbon and hydrogen. Benzene is a highly toxic compound, and long-term exposure to benzene can cause anemia, leukemia, and other medical conditions [1]. It is harmful to the eyes, skin, airway, nervous system, and lungs. 1,3: Benzene causes acute myeloid leukaemia (acute non-lymphocytic leukaemia), and there is limited evidence that benzene may also cause acute and chronic lymphocytic leukaemia, non-Hodgkin's lymphoma and multiple myeloma. 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